Influence of the dilution method on the intraocular duration of C3F8 in vitrectomy for macular hole: a randomized clinical trial

ABSTRACT Purpose: To compare the injection of small amounts of undiluted C3F8 with the traditional gas injection in vitrectomy for macular hole treatment. Methods: This clinical trial included 26 individuals divided into two groups. Group 1 received an intravitreal injection of 0.9-1.0 mL of 100% C3F8, and Group 2 received 15-20 mL of 20% C3F8. Results: The median intraocular gas duration was 31 days in Group 1 and 34 in Group 2. The median letter gains in corrected distance visual acuity for the 26th postoperative week were 20 letters in Group 1 and 12.5 in Group 2. The median intraocular pressure was normal in both groups. Primary anatomical success was 11/13 in both groups. Conclusions: The use of C3F8 gas in a small undiluted volume is an alternative that slightly reduces the duration of the gas without negatively affecting the anatomical and visual response.

Effect of preoperative use of topical prednisolone acetate, ketorolac tromethamine, nepafenac and placebo, on the maintenance of intraoperative mydriasis during cataract surgery: A randomized trial.

Purpose: To compare the effects of preoperative use of topical anti-inflammatory prednisolone acetate, ketorolac tromethamine, nepafenac and placebo, on the maintenance of intraoperative mydriasis during cataract surgery. Design: Randomized clinical trial. Materials and Methods: This single-center, masked, randomized clinical study comprised 140 patients scheduled for cataract surgery. Patients (35 in each group) were randomized to receive placebo, prednisolone acetate, ketorolac tromethamine 0.4% or nepafenac. These eye drops were administered three times daily for the two days prior to surgery. The pupillary diameters were measured by the surgeon using a compass prior to the corneal section and at the end of surgery. The primary outcome was the number of patients with pupil ≥ 6mm at the end of the surgery; the secondary outcome was the number of patients with pupil ≥ 6mm at the beginning of the surgery. Results: All the patients achieved pupil ≥ 6mm at the beginning of the surgery. The number of patients in the prednisolone (29/35), nepafenac (31/35) and ketorolac (30/35) groups with pupil ≥ 6mm was greater than in the placebo group in the maintenance of intraoperative mydriasis (19/35 – P =0.003). There was no statistical difference among the prednisolone, nepafenac and ketorolac groups in the maintenance of intraoperative mydriasis (P =.791). There were no complications during surgery or related to the preoperative use of the eye drops. Conclusion: Preoperative use of ketorolac, prednisolone and nepafenac was effective in maintaining intraoperative mydriasis when compared with placebo.

Hidrocistoma écrino e apócrino na pálpebra: casuística na Faculdade de Medicina de Bootucatu - São Paulo / Eyelid eccrine and apocrine hidrocystoma: occurrence at the Faculdade de Medicina de Botucatu - São Paulo

Os hidrocistomas palpebrais podem ser écrinos ou apócrinos. O objetivo era observar a ocorrência do hidrocistoma écrino e apócrino de localização palpebral, bem como a relação entre os diagnósticos clínico e histopatológico. Quarenta e dois pacientes, apresentando 52 lesões, atendidas no período de janeiro de 1990 a abril de 1999, no Hospital de Clínicas da Faculdade de Medicina de Botucatu - São Paulo, com diagnóstico histopatológico confirmado de hidrocistoma, foram avaliados quanto às variáveis sexo, idade, leocalização da lesão, tempo decorrido entre o aparecimento da lesão e o diagnóstico clínico, número de lesões e relação entre diagnóstico clínico e histopatológico. O hidrocistoma em suas duas formas foi responsável por 0,07 por cento das lesões removidas e examinadas histopatologicamente nesse serviço. Tanto o hidrocistoma apócrino, como o écrino, foram mais comuns em mulheres com idade superior a 40 anos. A maioria das lesões apresentava tempo de evolução variando entre um e cinco anos, estavam localizadas principalmente na pálpebra inferior, ocorrendo como lesão única. Os diagnósticos clínico e anatomopatológico foram concordantes em 67,31 por cento dos hidrocistomas apócrinos e 9,62 por cento dos écrinos. O hidrocistoma palpebral mais freqüente foi o apócrino (82,69 por cento), para o qual a concordância entre os diagnósticos clínico e histopatológico foi alta